Supercalifragi-depressed
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Joined 1 year ago
Cake day: July 17th, 2024
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But all the good buildings are concrete and steel! The combustible architecture is for peasants only
2·27 days agoI mean if one orifice HAD to accommodate a subwoofer, it’s honestly the best for multiple reasons. Cursed reasons. Great post OP
Y’all seen they movie circuit? Older set it films but Darling for practical effects and animatronic robots
Get that boy off the internet, the girl’s right!
That is on fact the point I was making, thank you for reaching it. There are multiple causes for excess urination and craving water, not necessarily sugar related. The takeaway is that both conditions should be considered… Or like, go to the doctor…?
Actually not quite, just looked up DI… Feel free to double fact check me on this:
`Below is a detailed fact‐check showing why diabetes insipidus (DI) is unrelated to blood sugar, and how it differs fundamentally from diabetes mellitus (DM).
Summary of Key Findings
Diabetes insipidus is a disorder of water balance caused by problems with antidiuretic hormone (ADH) production or response, leading to excessive urination and thirst; it has nothing to do with blood glucose regulation citeturn0search1turn0search6. In contrast, diabetes mellitus is a group of conditions characterized by insulin insufficiency or resistance, causing elevated blood sugar levels citeturn0search2turn0search3. Both share the Greek root “diabetes” (“to pass through”) because of polyuria, but are otherwise distinct diseases citeturn0search5turn0search7.
What Is Diabetes Insipidus?
Definition and Epidemiology
- DI is a rare disorder in which the kidneys cannot concentrate urine, producing up to 20 L/day of dilute urine instead of the normal 1–3 L/day citeturn0search1turn0search6.
- Prevalence is roughly 1 in 25,000 people worldwide citeturn0search11.
Mechanism: ADH Dysregulation
- Central DI: Insufficient ADH (vasopressin) production by the hypothalamus/pituitary citeturn0search0turn0search1.
- Nephrogenic DI: Renal tubules fail to respond to ADH citeturn0search5.
- Without ADH signaling, water reabsorption in the collecting ducts is impaired, so water is lost in urine.
Clinical Features
- Polyuria: Excessive urine volume, often > 10 L/day citeturn0search1turn0search6.
- Polydipsia: Intense thirst and preference for cold water citeturn0search1turn0search7.
- Risk of dehydration if fluid intake doesn’t match losses.
Diagnosis & Treatment
- Diagnosis: Water-deprivation test, measurement of ADH levels, and pituitary imaging (MRI) for central DI citeturn0search0turn0search1.
- Treatment:
- Central DI: Desmopressin (synthetic ADH) citeturn0search0turn0search1.
- Nephrogenic DI: Low-salt diet, thiazide diuretics, NSAIDs to reduce urine output citeturn0search1turn0search5.
What Is Diabetes Mellitus?
Definition and Epidemiology
- DM refers to disorders of glucose metabolism characterized by hyperglycemia (fasting plasma glucose ≥ 126 mg/dL or A1C ≥ 6.5 %) citeturn0search2turn0search14.
- Over 38 million Americans (~ 1 in 10) and hundreds of millions worldwide are affected citeturn0search3turn0search8.
Mechanism: Insulin and Glucose
- Type 1 DM: Autoimmune destruction of pancreatic β-cells → absolute insulin deficiency.
- Type 2 DM: Insulin resistance and relative insulin deficiency citeturn0search4turn0search12.
- Leads to impaired cellular glucose uptake and elevated blood sugar.
Clinical Features
- Polyuria & Polydipsia: Osmotic diuresis from glucose-rich urine citeturn0search2turn0search3.
- Polyphagia: Increased hunger.
- Long-term: Cardiovascular disease, neuropathy, retinopathy.
Diagnosis & Treatment
- Diagnosis: Fasting plasma glucose, oral glucose tolerance test, A1C measurement citeturn0search14.
- Treatment:
- Lifestyle: Diet, exercise, weight loss.
- Medications: Insulin for type 1; metformin, SGLT2 inhibitors, GLP-1 agonists for type 2 citeturn0search4turn0search18.
Why the Confusion?
- Both conditions cause frequent urination and thirst, hence share the name “diabetes” from the Greek for “siphon” citeturn0search5turn0search15.
- The key distinction is water vs. sugar regulation—DI involves ADH and free water clearance; DM involves insulin and glucose metabolism citeturn0search7turn0search2.
Bottom line: DI is not related to sugar intake or insulin. Cutting down on sugar will not affect DI. It’s a water‐balance disorder entirely separate from diabetes mellitus.`
Who says you can only have just one on one project? Itemize your tasks in a focused list and divvy up the task to delegates and you can keep the tasks simple enough and coordinate multiple agents on a single Advanced project that one conscience or entity wouldn’t be able to do alone. Fluffy ways of referring to tokens AI llm all that
Hilarious!
No symptoms! Only health!
Never too young to di-g up an old firearm and locate the nearest-mental health facility! Oh, they gutted those? Shoot the rich!
But this tracks with the hideous beach picture, are they both AI? Tub of shit man can be shaped like a tub of shit for all I care, but his adds weight to one side or the other regardless.
I don’t know how many years I rewround the clock while reading that entire paragraph but I am somewhere in the 1800s now surely. You can’t afford to live without baking bread for the village? How do you survive the winter on selling bread? I mean fuck this is a travesty if there ever was one… never mind the notion that Social Security is going away
You: Sustenance for you… Brain: ??? You: ???
Haha been there done that he days furiously swiping away from his own lamentable past
I too have not felt the grace of trickle down economics. Only vacuum up.
That’s just the delirium tremens sending a postcard
Delta8 was great if you could find anything of quality. Just enough head high but same body buzz as conventional, and can even be made from cheap bulk cbd and acid IN A LAB. Too much money in legalizing/taxing conventional bud though. At least done states have D9 at comparable rates
Things go quite well with high order direction and guidance. Don’t have that somewhere? You’ll spend an hour learning and gaining that experience, or you can turn off your high order guidance brain and thrash the llm you haven’t rate limited to maybe work it out in it’s own.