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Joined 3 years ago
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Cake day: July 6th, 2023

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  • Main Reasons Doctors Avoid Diclofenac

    Cardiovascular Risks: Diclofenac increases the risk of serious heart attacks, strokes, heart failure, and blood clots at a rate comparable to specialized COX-2 inhibitors (like rofecoxib). Studies show these cardiovascular risks can begin within just 30 days of starting the medication, even at low doses.

    The People’s Pharmacy

    +4

    Gastrointestinal Complications: Like other NSAIDs, it blocks protective prostaglandins in the stomach, which can lead to severe ulcers and a 4.5-fold higher risk of gastrointestinal bleeding compared to non-users.

    Pulse Today

    +1

    Kidney and Liver Strain: It can reduce blood flow to the kidneys—causing acute kidney injury or worsening blood pressure—and has been linked to drug-induced liver damage.

    Safer Alternatives Exist: Other nonselective NSAIDs like naproxen or low-dose ibuprofen generally offer a more favorable cardiovascular and safety profile for long-term use. Guidance from organizations like the GOV.UK Drug Safety Update explicitly contraindicates systemic diclofenac for patients with established ischemic heart disease, peripheral arterial disease, or heart failure.

    nhs.uk

    +1

    Ok, whatever man.











  • Do you or anyone here think we’ll learn the full story around 9/11 in our lifetimes? I was a kid in the CT suburbs of NYC in 2001 and for a very long time even casually questioning the narrative was sacrilege enough to be socially punished. Now it seems like the generation born afterwards is making memes about it like it didn’t change EVERYTHING about how we lived, and that’s no big deal? I remember talk about the specific floor that was hit, or one above or below it, had held records of extensive government debt that were just “lost”? Because of the nature of the event and the subsequent conspiracies, it’s hard to find level headed examination of how things happened and what we might still not be aware of. Like, iirc every member of the house of Saud in the US left the day before?