My understanding is that it means going, loosely, to the opposite side of the state of the major metropolitan area in that state. Upstate NY is the northwest part, upstate MA is the west part, upstate PA is the northeast part. I’m looking around, and it seems to also 1) only be used on a few states, 2) usually is on the north half (but not always), and 3) is somewhat interchangable with “rural”.

Similar metal in the human body one, Vitamin B12 has cobalt in it. Absolutely wild. I guess that’s not really commonly known but it’s still worth mentioning

Harmful ideas should be downvoted and repressed even if they took effort to type out, actually