

Thanks for the reply, it made me dig a bit deeper into this treatment (Casgevy) methodology and I learned some radical things about it! But the term gene editing in molecular/microbiology always refers to DNA, so these changes will be present in all future cells. Knowing the treatment used gene editing, I incorrectly assumed they just cut out the genetic sequence causing sickle cell. However, they edited the patients stem cells and reinfused them to create a permanent population of red blood cells with both the original sickle cell and fetal red blood cell traits! This works since fetal red blood cells don’t sickle due to their cell structure, meaning the sickle cell mutation remains in the patient’s DNA, so the edited cells still produce the trait to help with malaria.


Ben Affleck and Matt Damon were extras in Field of Dreams. But the most notorious actor which comes to mind is Clint Eastwood, he had a few uncredited parts plus a few extra roles in the 1950s!