Watched my coworker move her cursor to the right edge of her right-hand monitor to get it to over to the left side of her left-hand monitor. When I offered to show her how to adjust her display settings, she said she was used to it and didn’t want to change it. I don’t think I can walk by her desk while she’s working ever again.
What have you got?
There is at least one exception in my opinion where this is acceptable: when writing special characters with diacritics etc. (for example é, à), caps-lock can help capitalizing these letters since they often already require shift to be pressed. I’m aware that there are other ways (i.E. type the diacritic first, then the letter), but the caps-lock way seems easier to me.